Tag: PCOS symptoms

Can GLP-1s like Ozempic or Mounjaro help with PCOS? Our experts explain how they work, safety rules before pregnancy, and what to know about long-term use. Thank you to everyone who joined our recent webinar, “GLP-1 RAs: The PCOS Game Changer?”with Dr. Helen O’Neill and Dr. Paul Hardiman. The overwhelming response (over 600 attendees) confirmed the critical need for transparent, evidence-based information regarding these new therapies and their role in managing Polycystic Ovary Syndrome. We know the session generated significant interest and, crucially, many complex questions about everything from long-term safety and fertility planning to navigating the NHS and finding effective alternatives. This document serves as our expert-synthesised FAQ, acting as a crucial next step in your journey. It consolidates the questions we received into a concise, actionable resource. This FAQ will help you understand: By providing these clinically-vetted answers, we aim to empower you to have confident, informed conversations with your own healthcare providers, ensuring your PCOS management pathway is truly personalised and effective. Understanding PCOS and How GLP-1 Medications Fit In What does an irregular period mean in PCOS? According to the 2023 International Evidence-Based Guidelines (Teede et al., 2023), for women 3 years post-menarche up to the perimenopause stage, irregular menstrual cycles are defined as: OR Does everyone with PCOS have insulin resistance, even if my test results (such as glucose) have always been negative? No, not everyone with PCOS has insulin resistance (IR), but it is a critical part of the syndrome’s pathogenesis, documented in approximately 75% of women with PCOS (Cleveland Clinic, 2024).It is important to know that in the early stages of IR, standard tests like fasting glucose or HbA1c may appear normal because the pancreas is compensating by overproducing insulin (hyperinsulinemia). Therefore, monitoring glucose levels alone will not reliably detect the onset of IR. If my BMI is within the normal range (lean PCOS), would GLP-1 RAs still help with my symptoms (like skin, mood, or central adiposity)? Yes, GLP-1 RAs primarily target insulin sensitivity, which is thought to be a core driver of the syndrome, not just weight loss. Preclinical studies indicate that GLP-1 RAs can directly improve reproductive endocrinopathy by reversing high Luteinising Hormone (LH) levels and reducing serum testosterone and the Free Androgen Index (FAI) (Bednarz et al., 2022). These hormonal improvements offer a potential treatment strategy to manage hyperandrogenism-related symptoms regardless of BMI. What are the non-pill treatment options for managing acne and irregular periods in women with lean PCOS? For women with a normal BMI who wish to avoid the contraceptive pill, management focuses on lifestyle and targeted therapies: Ensure you consult a doctor or sexual health specialist before taking any supplements, vitamins or starting new treatments.  . At Hertility, we provide diagnostic testing with clinical grade results into your hormonal health. Get actionable insights into your reproductive health and egg count, and screen for up to 18 conditions such as PCOS. Receive in-depth insights, a comprehensive Doctor-written report, a clinically recommended Care Plan, and a complimentary Clinical Result Review Call. My GP is reluctant to diagnose or treat me for PCOS; what steps can I take to get appropriate care? PCOS diagnosis in the UK is guided by International Evidence-based Guidelines, typically using the Rotterdam Criteria (2 out of 3 features: irregular periods, hyperandrogenism, or polycystic ovarian morphology) (NICE, 2025; Teede et al., 2023). If you are struggling to get a diagnosis, ensure you have documented evidence of your symptoms (irregular periods, clinical signs like acne or hirsutism, and any relevant blood test or ultrasound reports). The Hertility Advanced Hormone & Fertility Test is a diagnostic test with clinical grade results into your hormonal health. Get actionable insights into your reproductive health and egg count, and screen for up to 18 conditions such as PCOS. Receive in-depth insights, a comprehensive Doctor-written report, a clinically recommended Care Plan, and a complimentary Clinical Result Review Call. We also provide fast referrals to leading UK private fertility clinics and treatment centres for comprehensive onward care. GLP-1 for PCOS: Safety, Effectiveness and Long-Term Use If I achieve my weight and symptom goals on a GLP-1 RA, will I regain the weight and symptoms if I stop taking it? Is this medication necessary long-term? GLP-1 RAs should generally be viewed as a long-term management strategy for a chronic metabolic condition. Clinical data does indicate a considerable likelihood of weight regain upon cessation, with weight often returning toward the pre-treatment baseline within about a year (Budini et al., 2025). However, the outlook is not universally negative; some evidence suggests that more than half of patients are able to maintain the achieved weight loss one year after discontinuing the medication (Szczesnowicz et al., 2023). Are there any known long-term health risks associated with taking GLP-1 RAs? While GLP-1 RAs are generally well-tolerated, rare but serious adverse events can occur, including acute pancreatitis and gallbladder issues (Szczesnowicz et al., 2023). Furthermore, long-term safety, particularly regarding combination therapy (e.g. with Metformin) in women with PCOS is an area that requires further research. It is crucial to obtain these prescriptions only from a doctor and fill them at a pharmacy, as unapproved or compounded versions have not been reviewed for safety or quality. If hair loss or fatigue occurs while taking a GLP-1 RA, what steps or supplements can help manage these side effects? Hair thinning or increased shedding (telogen effluvium) reported while on GLP-1 RAs is typically considered temporary and is usually attributed to the physiological stress of rapid weight loss or significant dietary changes, rather than the drug itself (Healthline, 2025). Management involves consulting your healthcare provider to assess your overall health and ensuring adequate nutritional intake, as inadequate consumption of key vitamins and minerals can impede the hair growth cycle. Vitamin D, iron and zinc are common deficiencies that can cause hair loss, but ensure you contact your doctor before taking any vitamins or supplements.  Through targeted dietary and lifestyle advice, Hertility works alongside you to help manage your symptoms of PCOS or help you […]

If you have been diagnosed with Polycystic Ovary Syndrome (PCOS) and are feeling a bit clueless or overwhelmed, we’re here to help. In this article, we explain all of the possible treatments for PCOS and how to effectively manage your symptoms. Quick facts: What is PCOS? PCOS is an extremely common reproductive health condition that affects up to 1 in 10 people assigned-female-at-birth. It can affect how the ovaries work and can cause an array of different symptoms, which can range in severity from person to person.  The good news is, that even if you are feeling overwhelmed or anxious at the outcome of your recent diagnosis, PCOS symptoms can be treated and managed with lifestyle changes. Symptoms of PCOS As with most conditions, the symptoms of PCOS vary from person to person, as does the severity of the symptoms. Not everyone with PCOS will experience all of these symptoms, but you need to have at least two of the below to have been diagnosed.   Other symptoms can include: What causes PCOS? Currently, the exact cause of PCOS is unknown but it often runs in families and can be related to abnormal hormone levels in the body, including high insulin.  Higher insulin levels also induce your ovaries to produce androgen hormones such as testosterone. An increase in androgen hormones can cause symptoms like excess hair growth (hirsutism) acne and alopecia.  High levels of insulin can also eventually cause insulin resistance. Because insulin metabolises carbohydrates in your body, those with insulin resistance are therefore unable to respond to glucose properly.  This can then lead to being overweight as your body is not able to absorb the sugars from your food into your liver and convert it into energy—so it is stored as fat instead. How to manage your PCOS symptoms The current treatment options for PCOS are symptomatic, as there is currently no cure. This means treatment is focused on treating and mitigating symptoms with lifestyle changes and certain medications.  Your treatment will follow patient-centred care, meaning you will have a say in your treatment and your doctors should respond by providing you with care that is responsive to your preference and needs. The first line of treatment they will recommend will be to make changes to your lifestyle. These include changing your diet, exercising, losing weight and taking part in activities to maintain healthy mental health.  Don’t underestimate the power of lifestyle changes. Making healthy choices and bringing positive changes to your lifestyle can create a major difference in your symptoms, allowing you to control them and improve your quality of life. With the right, tailored care plan, many people find that their PCOS symptoms can be controlled and that they don’t present any further problems for them. Let’s take a look at some of the lifestyle changes involved in PCOS symptom management. PCOS diet and nutrition Some research suggests that following a healthy balanced diet is a significant way to manage your PCOS—it can regulate your period and ovulation and reduce the presence of symptoms like acne and hirsutism. High GI carbs Vs low GI and weight loss If you are currently overweight, losing weight and maintaining a healthy weight is crucial for managing PCOS.  The more overweight you are the more complications you will face with PCOS as well as having a higher risk of developing other long term health conditions. There are many different PCOS diets that people recommend, but a healthy and sustainable option is a low glycaemic index (G.I) diet. This involves substituting high GI carbs with low GI carbs which can help PCOS sufferers lose weight efficiently. Low GI carbs increase blood glucose levels very slowly, whereas high GI foods are digested rapidly, which can cause spikes in your glucose and insulin levels.  A great book that explains the G.I diet very well is ‘ The Low GL Diet Bible’ by Patrick Holford, it contains a list of foods that you can substitute your daily carbs with. Here are some great examples of Low GI carbs that you could incorporate into your diet: Following a low GI carbs diet is generally the key piece of advice that clinicians and dieticians will advise in the case of any PCOS diagnosis and will likely form the basis of a PCOS specific nutritional care plan.  However, there are other foods and simple switches that you can incorporate into your diet which may help to further reduce your symptoms too. A PCOS friendly food list may contain: If you’d like help with anything regarding PCOS specific nutrition, you can book a consultation with one of our Fertility Nutritionists who will be able to help you with a nutritional care plan. Reducing fat and salt As well as managing and decreasing your carbohydrate intake, you should also manage your fat and salt intake and make sure you’re taking in all the necessary vitamins and minerals. Try to keep your salt intake to a maximum of 2,300 mg per day.Also, increasing the intake of whole foods aids weight loss and helps to maintain a healthy balanced diet.  Although losing weight isn’t so easy for PCOS sufferers, it is totally worth it—just a decrease in 5% of overall body weight can significantly improve symptoms. PCOS and exercise benefits Like losing weight, exercise increases metabolism and may help to improve many of your symptoms. When exercising, the main goal is to lose weight in the abdomen and reduce fat around the organs.  This will help to support your endocrine system, which secretes and regulates your hormones, including your insulin and testosterone levels.  If you’re new to regularly exercising, it’s best to start slowly, steadily increasing your workouts as well as the time spent working out. In the long run, this will be much easier to maintain.  Cardio is great for heart health, with things like swimming, hiking and running great for getting a sweat on. But there is a misconception that you will only lose weight with cardio, it’s a total myth!  […]